The COVID-19 resistance study also known as DIRECTS (Detecting Innate Protection against SARS-CoV-2) is a research study to understand why some people are naturally resistant to developing COVID-19.
We are conducting two studies to help us understand this resistance – DIRECTS-1 with St James's Hospital healthcare workers and their household members, and DIRECTS-2 with members of the public. If you’re interested in this study or would like more information, please get in touch!
(the three main outcomes of viral exposure)
resistant → exposed to the virus but not infected.
asymptomatic → infected but displaying no signs of COVID-19.
symptomatic → infected and displaying typical signs of COVID-19.
(Detecting Innate Resistance against SARS-CoV-2)
DIRECTS is a research study aiming to understand why some people are naturally resistant to getting COVID-19 infection. Identifying who is resistant and how they are resistant could have a major impact on public health measures, vaccine development and basic understanding of viral infections. There are two components to DIRECTS:
DIRECTS-1 is focused on St James's Hospital healthcare workers (HCWs) and their close household contacts.
DIRECTS-2 seeks volunteers from the general public who did not contract COVID-19 despite being close household contacts of individuals previously positive for COVID-19. If you don't think you're eligible to participate in DIRECTS-1, fill out the DIRECTS-2 questionnaire.
The TCD/SJH team tackling this project has extensive globally recognised research experience into:
Immune responsiveness to viral infection.
Together with their international collaborators, access to some of the most sophisticated technologies and research facilities in the world
Significant experience in the care of patients and healthcare workers with COVID-19 infection.
If you’re interested in this study or would like more information, please get in touch with us! Study information is listed below. If you have further questions please see our FAQ section or feel free to contact us.